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La terapia fotodinámica es una alternativa para el tratamiento del acné facial gracias a sus propiedades bactericidas y antinflamatorias. El presente trabajo se centró en evaluar la eficacia de la terapia fotodinámica (TFD) y ácido 5‑aminolevulínico (ALA) como fotosensibilizante en acné facial inflamatorio leve a moderado. Se realizó a través de un estudio de serie de casos, los cuales fueron tratados con 2 sesiones de TFD (luz azul: 423 nm y roja: 640 nm) - 0,1% ALA a nivel del rostro durante 10 minutos con cada tipo de luz. Un total de 5 pacientes femeninas fueron incorporadas al estudio, con un rango entre 16 y 26 años edad, la mayoría (80,0%) fototipo IV, las cuales presentaban una severidad moderada (60,0%), leve (20,0%) y practicamente sin lesiones (20,0%) de acné, según puntaje de la Escala Global Evaluación del Acné (GEA). Se evidenció que el número de lesiones de acné fue disminuyendo de forma gradual conforme la aplicación de las diferentes sesiones, al igual que la severidad del acné en las pacientes incorporadas al estudio disminuyó (p=0,035) a partir de la primera sesión. En conclusión, la terapia de TFD-ALA es un protocolo seguro y eficaz para el tratamiento del acné, el cual presentó una disminución de la severidad en el 60% de los pacientes con disminución significativa del 53% para el número de lesiones y 67% de la severidad del acné, lo que conllevó a un cambio significativo en la disminución del grado de severidad del acné en las pacientes incorporadas al estudio.
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