Abstract
Intense pulsed light (IPL) has been widely studied in the treatment of photoaging in darker skin types and across different ethnic groups, particularly in Asian populations; however, evidence in Latin skin remains limited. The objective of this study was to evaluate the efficacy of IPL in Colombian women with facial photoaging. A descriptive cross-sectional study was conducted using medical records of 63 patients treated with IPL alone or in combination with other light-based therapies. Clinical improvement was assessed by two independent investigators blinded to the intervention, and global averages were calculated according to treatment type and skin phototype. Results showed that IPL, either alone or combined with Nd: YAG laser, produced significant improvement in fine lines, deep wrinkles, mottled pigmentation, erythema, telangiectasias, laxity, and overall facial appearance in Latin American patients with skin phototypes II to V. In conclusion, IPL can be considered an effective and safe therapeutic device for facial rejuvenation in Latin women, with a positive impact on quality of life and minimal adverse effects.
References
1. Knight JM, Kautz G. Sequential facial skin rejuvenation with intense pulsed light and non-ablative fractionated laser resurfacing in fitzpatrick skin type II-IV patients: A prospective multicenter analysis. Lasers Surg Med [Internet]. 2019 Feb 1 [cited 2023 Mar 11];51(2):141–9. Available from: https://pubmed.ncbi.nlm.nih.gov/30091207/
2. Hamilton M, Campbell A, Holcomb JD. Contemporary Laser and Light-Based Rejuvenation Techniques. Facial Plast Surg Clin North Am [Internet]. 2018 May 1 [cited 2023 Mar 11];26(2):113–21. Available from: https://pubmed.ncbi.nlm.nih.gov/29636145/
3. Goldman MP, Weiss RA, Weiss MA. Intense pulsed light as a nonablative approach to photoaging. Dermatol Surg [Internet]. 2005 [cited 2023 Mar 11];31(9 Pt 2):1179–87. Available from: https://pubmed.ncbi.nlm.nih.gov/16176769/
4. Patriota RCR, Rodrigues CJ, Cucé LC. Intense pulsed light in photoaging: a clinical, histopathological and immunohistochemical evaluation. An Bras Dermatol [Internet]. 2011 Nov [cited 2023 Mar 11];86(6):1129–33. Available from: https://pubmed.ncbi.nlm.nih.gov/22281900/
5. Nassar S, Assem M, Mohamed D, Hassan G. The efficacy of radiofrequency, intense pulsed light and carboxytherapy in facial rejuvenation. J Cosmet Laser Ther [Internet]. 2020 [cited 2023 Mar 11];22(6–8):256–64. Available from: https://pubmed.ncbi.nlm.nih.gov/33840336/
6. Sales AFS, Pandolfo IL, de Almeida Cruz M, Parisi JR, Garcia LA, Martignago CCS, et al. Intense Pulsed Light on skin rejuvenation: a systematic review. Arch Dermatol Res [Internet]. 2022 Nov 1 [cited 2023 Mar 11];314(9):823–38. Available from: https://pubmed.ncbi.nlm.nih.gov/34609598/
7. Li YH, Chen JZS, Wei HC, Wu Y, Liu M, Xu YY, et al. Efficacy and safety of intense pulsed light in treatment of melasma in Chinese patients. Dermatol Surg [Internet]. 2008 [cited 2022 Aug 19];34(5):693–701. Available from: https://pubmed-ncbi-nlm-nih-gov.ezproxy.uniandes.edu.co/18318729/
8. Yi J, Hong T, Zeng H, Li P, Li P, Wang S, et al. A Meta-analysis-Based Assessment of Intense Pulsed Light for Treatment of Melasma. Aesthetic Plast Surg. 2020 Jun 1;44(3):947–52.
9. Goldman MP, Gold MH, Palm MD, Colón LE, Preston N, Johnson LA, et al. Sequential treatment with triple combination cream and intense pulsed light is more efficacious than sequential treatment with an inactive (control) cream and intense pulsed light in patients with moderate to severe melasma. Dermatol Surg [Internet]. 2011 Feb [cited 2022 Aug 19];37(2):224–33. Available from: https://pubmed-ncbi-nlm-nih-gov.ezproxy.uniandes.edu.co/21269349/
10. Tong LG, Wu Y, Wang B, Xu XG, Tu HD, Chen HD, et al. Combination of fractional QSRL and IPL for melasma treatment in Chinese population. J Cosmet Laser Ther [Internet]. 2017 Jan 2 [cited 2022 Aug 19];19(1):13–7. Available from: https://pubmed-ncbi-nlm-nih-gov.ezproxy.uniandes.edu.co/27594596/
11. Lee YS, Lee YJ, Lee JM, Han TY, Lee JH, Choi JE. The Low-Fluence Q-Switched Nd: YAG Laser Treatment for Melasma: A Systematic Review. Medicina (Kaunas) [Internet]. 2022 Jul 14 [cited 2022 Aug 19];58(7):936. Available from: http://www.ncbi.nlm.nih.gov/pubmed/35888655
12.Yang J, Zeng J, Lu J. Mechanisms of ultraviolet-induced melasma formation: A review. J Dermatol [Internet]. 2022 Aug 10 [cited 2022 Aug 19]; Available from: https://pubmed-ncbi-nlm-nih-gov.ezproxy.uniandes.edu.co/35946331/
13. Espósito ACC, Cassiano DP, da Silva CN, Lima PB, Dias JAF, Hassun K, et al. Update on Melasma-Part I: Pathogenesis. Dermatol Ther (Heidelb) [Internet]. 2022 Jul 29 [cited 2022 Aug 19]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/35904706
14. Ortonne J, Arellano I, Berneburg M, Cestari T, Chan H, Grimes P, et al. A global survey of the role of ultraviolet radiation and hormonal influences in the development of melasma. J Eur Acad Dermatol Venereol [Internet]. 2009 Nov [cited 2022 Sep 19];23(11):1254–62. Available from: https://pubmed.ncbi.nlm.nih.gov/19486232/
15. Tamega ADA, Miot LDB, Bonfietti C, Gige TC, Marques MEA, Miot HA. Clinical patterns and epidemiological characteristics of facial melasma in Brazilian women. Journal of the European Academy of Dermatology and Venereology. 2013 Feb;27(2):151–6.
16. Espósito ACC, Brianezi G, de Souza NP, Miot LDB, Miot HA. Exploratory Study of Epidermis, Basement Membrane Zone, Upper Dermis Alterations and Wnt Pathway Activation in Melasma Compared to Adjacent and Retroauricular Skin. Ann Dermatol [Internet]. 2020 Apr 1 [cited 2022 Aug 19];32(2):101–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/33911720
17. Gautam M, Patil S, Nadkarni N, Sandhu M, Godse K, Setia M. Histopathological comparison of lesional and perilesional skin in melasma: A cross-sectional analysis. Indian J Dermatol Venereol Leprol. 2019 jul 1;85(4):367–73.
18.Cassiano DP, Espósito ACC, Hassun KM, Lima MMD de A, Lima EV de A, Miot LDB, et al. Histological changes in facial melasma after treatment with triple combination cream with or without oral tranexamic acid and/or microneedling, a randomised clinical trial. Indian J Dermatol Venereol Leprol [Internet]. 2022 Mar 11 [cited 2022 Aug 19]; 0:1–10. Available from: http://www.ncbi.nlm.nih.gov/pubmed/35389028
19.Artzi O, Horovitz T, Bar-Ilan E, Shehadeh W, Koren A, Zusmanovitch L, et al. The pathogenesis of melasma and implications for treatment. J Cosmet Dermatol [Internet]. 2021 Nov 1 [cited 2022 Aug 19];20(11):3432–45. Available from: https://pubmed-ncbi-nlm-nih-gov.ezproxy.uniandes.edu.co/34411403/
20. Goldman MP, Gold MH, Palm MD, Colón LE, Preston N, Johnson LA, et al. Sequential treatment with triple combination cream and intense pulsed light is more efficacious than sequential treatment with an inactive (control) cream and intense pulsed light in patients with moderate to severe melasma. Dermatol Surg [Internet]. 2011 Feb [cited 2022 Aug 19];37(2):224–33. Available from: https://pubmed-ncbi-nlm-nih-gov.ezproxy.uniandes.edu.co/21269349/
21. Na SY, Cho S, Lee JH. Intense Pulsed Light and Low-Fluence Q-Switched Nd:YAG Laser Treatment in Melasma Patients. Ann Dermatol [Internet]. 2012 Aug [cited 2022 Aug 19];24(3):267–73. Available from: https://pubmed-ncbi-nlm-nih-gov.ezproxy.uniandes.edu.co/22879709/
22. Zaleski L. Treatment of Melasma and the Use of Intense Pulsed Light: A Review - JDDonline - Journal of Drugs in Dermatology [Internet]. [cited 2022 Aug 19]. Available from: https://jddonline.com/articles/treatment-of-melasma-and-the-use-of-intense-pulsed-light-a-review-S1545961612P1316X/
23. Adel S, Serri A, Abd El-Raheem T. Study of autologous platelet-rich-plasma versus its combination with intense pulsed light in treatment of melasma. Dermatol Ther. 2021 Jul 1;34(4).
24.Gulfan MCB, Wanitphakdeedecha R, Wongdama S, Jantanapornchai N, Yan C, Rakchart S. Efficacy and Safety of Using Noninsulated Microneedle Radiofrequency Alone Versus in Combination with Polynucleotides for the Treatment of Melasma: A Pilot Study. Dermatol Ther (Heidelb) [Internet]. 2022 Jun 1 [cited 2022 Aug 19];12(6):1325–36. Available from: http://www.ncbi.nlm.nih.gov/pubmed/35538360
25. Tong LG, Wu Y, Wang B, Xu XG, Tu HD, Chen HD, et al. Combination of fractional QSRL and IPL for melasma treatment in Chinese population. J Cosmet Laser Ther [Internet]. 2017 Jan 2 [cited 2022 Aug 19];19(1):13–7. Available from: https://pubmed-ncbi-nlm-nih-gov.ezproxy.uniandes.edu.co/27594596/
26. Jalalat S, Weiss E. Cosmetic Laser Procedures in Latin Skin. J Drugs Dermatol. 2019 Mar 1;18(3):s127-131. PMID: 30909360.

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