Keywords
burns
fractional CO₂ laser
exosomes
POSAS
VSS
How to Cite
Abstract
Post-burn scars represent a clinical challenge due to their aesthetic, functional, and psychological impact on patients. This has prompted the development of innovative therapies aimed at promoting skin regeneration and improving quality of life. The objective of this study was to evaluate the effectiveness of fractional CO₂ laser therapy, applied as monotherapy and in combination with synthetic exosomes (dual therapy), in the treatment of burn scars.Twelve scars were treated over four sessions using two protocols: fractional CO₂ laser alone and fractional CO₂ laser combined with exosomes. From the second session onward, both approaches showed significant improvements (p < 0.05) in flexibility, thickness, contour, elasticity, and surface reduction, based on the Vancouver Scar Scale (VSS) and the Patient and Observer Scar Assessment Scale (POSAS). Dual therapy demonstrated superior outcomes (p < 0.05), with improvements of 33.5% in VSS, 46.1% in physician POSAS, and 40.8% in patient POSAS, outperforming monotherapy. In conclusion, fractional CO₂ laser therapy particularly when combined with synthetic exosomes offers a safe, effective, and non-invasive outpatient alternative for the treatment of burn scars, contributing to both functional and aesthetic skin restoration.
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