Keywords
neck
dermis
epidermis
exosomes
fractional CO₂ laser
laxity
rejuvenation
SLEB
How to Cite
Abstract
The neck plays a key role in the aesthetic perception of aging, prompting growing demand for non-invasive rejuvenation procedures. This study evaluated the efficacy of fractional CO₂ laser therapy, applied as monotherapy and in combination with synthetic exosomes derived from plant stem cells, in patients with cervical skin laxity and wrinkles. Fourteen women (28 heminecks), aged 35 to 58 years, were included. Most had Fitzpatrick skin phototype III (78.6%) and presented moderate laxity (85.7%) and wrinkle severity (71.4%) according to the IBSA and Fitzpatrick Wrinkle Classification Scale (FWCS), respectively. All patients received three sessions of fractional CO₂ laser across the entire neck. Exosomes were applied to the left hemineck, while saline solution was used as placebo on the right. Both protocols showed statistically significant improvements (p < 0.05) in reducing laxity and wrinkles, with superior results in the combined treatment. Ultrasound imaging revealed increased dermal thickness and reduced SLEB, with significant changes on the side treated with laser and exosomes. Patient satisfaction was higher with the dual therapy. In conclusion, fractional CO₂ laser combined with exosomes offers a safe, effective, and well-tolerated approach for neck rejuvenation, improving both structural and aesthetic parameters
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